Overview:

Cofilin 1 (non-muscle), also known as CFL1, is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner (1). It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus (2). CFL1 processed proteins are most probably produced by HIV-1 protease digestion.

Gene Aliases:

CFL1, CFL

Genbank Number:

NM_005507

References:

1. Maciver, S.K. et al: The ADF/cofilin family: actin-remodeling proteins.". Genome Biol. 2002; 3 (5): reviews 3007.

2. Samstag, Y. Et al: Iteraction of cofilin with the serine phosphatases PP1 and PP2A in normal and neoplastic human T lymphocytes.". Adv. Enzyme Regul. 2004;97–211.