Recombinant full-length human SMAD5 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. S14-30G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
S14-30G-20 | 20 ug | $215 | |
S14-30G-50 | 50 ug | $435 | |
S14-30G-BULK | BULK | Contact Us |
Overview:
SMAD5 is a member of the SMAD family and mediates signaling by the transforming growth factor-beta (TGFβ) superfamily and related ligands (1). SMAD5 plays a critical role in the signaling pathway by which TGFβ inhibits the proliferation of human hematopoietic progenitor cells. SMAD5 is up-regulated in gastric epithelial cells during the infection of the pathogen Helicobacter pylori and it mediates apoptosis of gastric epithelial cells induced by H. pylori infection (2). In mature human B cells, bone morphogenetic protein 6 (BMP-6) inhibits cell growth and rapidly induces phosphorylation of SMADs 5 and 8.
Gene Aliases:
Dwfc, JV5-1, MADH5, DKFZp781C1895, DKFZp781O1323
Genbank Number:
References:
1. Heldin, C.H. et al: TGF-beta signalling from cell membrane to nucleus through SMAD proteins". Nature, 1997, 390 (6659): 465–71.
2. Nagasko, T. et al: Up-regulated Smad5 mediates apoptosis of gastric epithelial cells induced by Helicobacter pylori infection. J Biol Chem. 2003 Feb 14;278(7):4821-5.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~82 kDa
There are no related publications available for this product.
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