Overview:

PRMT1 is a protein arginine methyltransferase that functions as a histone methyltransferase specific for histone H4. PRMT1 specifically methylates arginine-3 of histone H4 in vitro and in vivo. Methylation of arg3 by PRMT1 facilitates subsequent acetylation of histone H4 tails by p300 (1). PRMT1 performs methylation of arg31 of STAT1 and this is required for transcription induced by IFN-alpha/IFN-beta (2). Arginine methylation of STAT1 is an additional posttranslational modification regulating transcription factor function, and alteration of arginine methylation might be responsible for the lack of interferon responsiveness observed in many malignancies.

Gene Aliases:

ANM1; HCP1; IR1B4

Genbank Number:

Q99873-3

References:

1. Wang, H. et al: Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Science 293: 853-857, 2001.

2. Mowen, K. A. et al: Arginine methylation of STAT1 modulates IFN-alpha/beta-induce d transcription. Cell 104: 731-741, 2001.