Overview:

Euchromatic histone-lysine N-methyltransferase 1 (EHMT1) is in charge of the mono- and demethylation of lysine-9 of histone H3. EHMT1 is found in a multimeric protein complex containing chromatin modifiers, which contributes to silencing of MYC- and E2F-responsive genes during G0 phase of cell cycle (1). EHMT1 plays a role in epithelial-to-mesenchymal transition and tumor invasion by repressing expression of tumour suppressor genes (2). Additionally, EHMT1 also methylates non-histone proteins such as lysine-373 of p53 (3).

Gene Aliases:

GLP; GLP1; Eu-HMTase1; EUHMTASE1; FP13812; KMT1D; bA188C12.1

Genbank Number:

NM_024757

References:

1. Ogawa, H., et al. A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells. Science. 296(5570):1132-6, 2002.

2. Kokura, K., et al. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J. 29(21):3673-87, 2010.

3. Huang, J., et al. G9a and Glp methylate lysine 373 in the tumor suppressor p53. J Biol Chem. 285(13):9636-41, 2010.