Overview:

Homo sapiens suppressor of variegation 3-9 homolog 2 (SUV39H2) is encoded by the SUV39H2 gene and belongs to the histone-lysine methyltransferase family and Suvar3-9 subfamily, It contains an N-terminal chromodomain and a C-terminal SET domain. It trimethylates lysine 9 of histone H3, creating a binding site for the chromo domain of HP1 for epigenetic transcriptional repression. Deregulation of SUV39H2 interferes with mammalian higher-order chromatin organization.

Gene Aliases:

KMT1B; FLJ23414

Genbank Number:

BC007754

References:

1. Rea S, et al: Regulation of chromatin structure by site-specific histone H3 methyltransferases. Nature.10;406(6796):593-9, 2000.

2. Aagaard L, et al: Functional mammalian homologues of the Drosophila PEV-modifier Su(var)3-9 encode centromere-associated proteins which complex with the hetero-chromatin component M31. EMBO J. 1;18(7):1923-38, 1999.