Recombinant full-length human PRMT4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P365-380DG
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| P365-380DG-05 | 5 ug | $259 | |
| P365-380DG-10 | 10 ug | $380 | |
| P365-380DG-BULK | BULK | Contact Us |
Overview:
Histone-arginine methyltransferase, Coactivator-associated arginine methyltransferase-1 (CARM1 or PRMT4) methylates (mono- and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in several proteins involved in DNA packaging, transcription regulation, pre-mRNA splicing, and mRNA stability. It is known to enhance transcriptional activation by nuclear receptors through interactions with the coactivators p160 and cAMP response element binding protein-binding protein (CBP) and methylation of histone H3 at arginine 17 (H3-R17).
Gene Aliases:
CARM1
Genbank Number:
References:
1. Miao F, Li S, Chavez V, Lanting L, Natarajan R. Coactivator-associated arginine methyltransferase-1 enhances nuclear factor-kappaB-mediated gene transcription through methylation of histone H3 at arginine 17. Mol Endocrinol. 20(7):1562-73. 2006.
Specific Activity:
Sample Enzyme Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
92 kDa
Apoptosis/Autophagy, Cancer, Cell Cycle, Neurobiology
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et al., PRMT1-dependent regulation of RNA metabolism and DNA damage response sustains pancreatic ductal adenocarcinoma Nature Communications July 2021 
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