Overview:

Guanine nucleotide-binding proteins (G proteins) are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits, and function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. G protein subunit alpha i2 (GNAI2) regulates cellular viability and migration and plays roles in a wide range of hormone signaling.

Gene Aliases:

GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1

Genbank Number:

NM_002070

References:

1. Neves SR, et al: G protein pathways. Science. 2002 May 31; 296(5573):1636-9.

2. Raymond JR Jr, et al: Suppression of GNAI2 message in ovarian cancer. J Ovarian Res. 2014 Jan 14;7:6. doi:10.1186 /1757-2215-7-6.