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DRAK1 (STK17A), Active

Recombinant full-length human DRAK1 (STK17A) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. S33-10G


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Catalog No. Pack Size Price (USD)
S33-10G-05 5 ug $226
S33-10G-10 10 ug $325
S33-10G-BULK BULK Contact Us  


Overview:

DRAK1 (STK17A) is a member of the DAP kinase-related apoptosis-inducing protein kinase family. DRAK1 encodes an autophosphorylated nuclear protein with a protein kinase domain which has apoptosis-inducing activity. DRAK1 is capable of autophosphorylation and of phosphorylating myosin light chain as an exogenous substrate. The noncatalytic C terminus of DRAK1 is crucial for full kinase activity (1). DRAK1 is highly expressed in placenta, but also in heart, lung, skeletal muscle, kidney, and pancreas. DRAK1 act as a novel direct target of p53 and a modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells (2).


Gene Aliases:

DRAK1; STK17A


Genbank Number:


References:


1. Sanjo, H. et.al: DRAKs, novel serine/threonine kinases related to death-associated protein kinase that trigger apoptosis. J. Biol. Chem. 273: 29066-29071, 1998.

2. Mao P, et.al: Serine/threonine kinase 17A is a novel p53 target gene and modulator of cisplatin toxicity and reactive oxygen species in testicular cancer cells. J Biol Chem. 2011 Jun 3;286(22):19381-91.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~83kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Metabolic Disorder, Ser/Thr Kinases


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