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DYRK3, Active

Recombinant human DYRK3 (63-end) was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. D11-11G


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Catalog No. Pack Size Price (USD)
D11-11G-05 5 ug $226
D11-11G-10 10 ug $325
D11-11G-BULK BULK Contact Us  


Overview:

DYRK3 or dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 is belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. DYRK3 expressed in E. coli undergoes tyrosine autophosphorylation and catalyzes phosphorylation of histones H3 and H2B in vitro (1). DYRK3 regulate different steps of the caveolar cycle (2). DYRK3 can promote cell survival through phosphorylation and activation of SIRT1. DYRK3 directly phosphorylate SIRT1 at Thr(522), promoting deacetylation of p53.


Gene Aliases:

RED, REDK, DYRK5


Genbank Number:


References:


1. Becker, W. et. al : Sequence characteristics, subcellular localization, and substrate specificity of DYRK-related kinases, a novel family of dual specificity protein kinases. J. Biol. Chem. 273: 25893-25902, 1998.

2. Pelkmans. L. et.al: Kinase-regulated quantal assemblies and kiss-and-run recycling of caveolae. Nature 436: 128-133, 2005.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~95 kDa



RESEARCH AREAS

AKT/PKB Pathway, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, Ser/Thr Kinases, WNT Signaling


RELATED PRODUCTS


  Kinase Dilution Buffer III, K23-09

  Kinase Assay Buffer I, K01-09

  ATP Stock Solution, A50-09

  DYRKtide, D96-58


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