Recombinant full-length human AURORA B (D200A) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A31-12G
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
A31-12G-20 | 20 ug | $215 | |
A31-12G-50 | 50 ug | $435 | |
A31-12G-BULK | BULK | Contact Us |
Overview:
AURORA B is a member of the Aurora kinase family that associates with microtubules during chromosome movement and segregation. AURORA B localizes to the microtubules near kinetochores, specifically to the specialized microtubules called K-fibers (1). AURORA B inhibits the microtubule depolymerizing activity of mitotic centromere-associated kinesin (MCAK) by phosphorylating MCAK on Ser92 (2). This phosphorylation also regulates MCAK translocalization from kinetochores to the centromere. AURORA B has been identified as a target for the development of new anticancer agents since inhibition of AURORA B gives rise to the more pronounced antiproliferative phenotype.
Gene Aliases:
AURKB, AIK2; AIM1; ARK2; AurB; IPL1; AIM-1; STK12
Genbank Number:
References:
1. Shannon, K B. et al: Chromosome dynamics: new light on Aurora B kinase function. Curr Biol. 2002 Jul 9;12(13):R458-60.
2. Andrews, P. D. et al: Aurora B regulates MCAK at the mitotic centromere. Dev. Cell 6: 253-268, 2004.
Purity:
Sample purity data. For lot specific datasheet, please refer to the respective datasheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
Approx MW 65 kDa.
Apoptosis/Autophagy, Cancer, Cell Cycle, Ser/Thr Kinases
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