MBP Protein
Recombinant full length human MBP was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. M42-54G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M42-54G-20 | 20 ug | $215 | |
| M42-54G-50 | 50 ug | $435 | |
| M42-54G-BULK | BULK | Contact Us |
Recombinant full length human MBP was expressed in E. coli cells using a N-terminal GST tag.
Catalog No. M42-54G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| M42-54G-20 | 20 ug | $215 | |
| M42-54G-50 | 50 ug | $435 | |
| M42-54G-BULK | BULK | Contact Us |
Overview:
MBP or Myelin Basic Protein forms dimers across the cytoplasmic apposition during the formation of myelin. The region of the protein involved in folding, polymerization and substrate specificities is conserved in various species and it may have a specialized role in protein-lipid interactions in the myelin membrane (1). MBP is an efficient substrate for numerous protein kinases and share similarities with the MARCKS protein in terms of having extended conformations regulated by their environment, N-terminal modifications, a dual nature of interactions with lipids, and binding to actin and Ca2+-calmodulin (2).
Genbank Number:
References:
1. Chapman, B.E. et al: Conformation of myelin basic protein and its role in myelin formation. Adv Exp Med Biol. 1978;100:207-20.
2. Harauz, G. et al: Analogous structural motifs in myelin basic protein and in MARCKS. Mol Cell Biochem.2000 Jun;209(1-2):155-63.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~36 kDa
C; Weerapana Wang et al., A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles Nature Methods May 2015 10.1038/nmeth.2759
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Liu Haidan et al., A Chrysin Derivative Suppresses Skin Cancer Growth by Inhibiting Cyclin-dependent Kinases Journal of Biological Chemistry September 2013 10.1074/jbc.M113.464669
Young Lee Jin et al., Gambogic Acid Disrupts Toll-like Receptor4 Activation by Blocking Lipopolysaccharides Binding to Myeloid Differentiation Factor 2 Toxicological Research March 2015 10.5487/TR.2015.31.1.011
Lee Rubin et al., METHODS, COMPOSITIONS AND KITS FOR PROMOTING MOTOR NEURON SURVIVAL AND TREATING AND DIAGNOSING NEURODEGENERATIVE DISORDERS Patent US 20160082015 April 2016
et al., Therapeutic targeting of nemo-like kinase in primary and acquired endocrine-resistant breast cancer Clinical cancer research : an official journal of the American Association for Cancer Research May 2021
et al., Expression and purification of active human kinases using Pichia pastoris as a general-purpose host. Protein expression and purification August 2021
ERK/MAPK Pathway, Neurobiology
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