Recombinant full-length human TPX2 protein was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag. This product can be used for Aurora A activation in vitro.
Catalog No. T40-30H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| T40-30H-20 | 20 ug | $160 | |
| T40-30H-50 | 50 ug | $336 | |
| T40-30H-BULK | BULK | Contact Us |
Overview:
TPX2 is a nuclear proliferation-associated protein whose expression is restricted to cell cycle phases S, G2, and M (1). It mainly expressed in the lung carcinoma cell lines and also found in adult placenta, skeletal muscle, thymus, testis, and small intestine and in fetal brain, liver, and kidney.TPX2 is required for targeting STK6 to the spindle apparatus, and that STK6 may regulate the function of TPX2 during spindle assembly. TPX2 is mailnly function in mitotic spindle assembly likely contributes to its role in chromosome stability control and tumor suppression (2).
Gene Aliases:
DIL2, p100, DIL-2, HCTP4, FLS353, HCA519, REPP86, C20orf1, C20orf2, GD:C20orf1
Genbank Number:
References:
1. Heidebrecht, H. J. et.al: p100: a novel proliferation-associated nuclear protein specifically restricted to cell cycle phases S, G2, and M. Blood 90: 226-233, 1997.
2. Joukov, V.et.al: The BRCA1/BARD1 heterodimer modulates Ran-dependent mitotic spindle assembly. Cell 127: 539-552, 2006.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~110 kDa
Apoptosis/Autophagy, Cancer, Cell Cycle, Invasion/Metastasis, Neurobiology
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Jian-Fu Chen et al., Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size Nature Communications May 2015 10.1038/ncomms4885 
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