TRKA, Active
Recombinant human TRKA (440-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. N16-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N16-11G-05 | 5 ug | $226 | |
| N16-11G-10 | 10 ug | $325 | |
| N16-11G-BULK | BULK | Contact Us |
Recombinant human TRKA (440-end) was expressed by baculovirus in Sf9 insect cells using a N-terminal GST tag.
Catalog No. N16-11G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| N16-11G-05 | 5 ug | $226 | |
| N16-11G-10 | 10 ug | $325 | |
| N16-11G-BULK | BULK | Contact Us |
Overview:
TRKA is a member of the trk proto-oncogene family and encodes a 140-kilodalton, membrane-spanning protein tyrosine kinase that is the functional receptor for nerve growth factor (NGF). NGF elicits the rapid phosphorylation of gp140trk on tyrosine residues leading to increased c-Fos expression, DNA synthesis and morphologic transformation (1). A decreased expression of TRKA on the striatal cholinergic neurons has been observed which may contribute, when it reaches a crucial threshold, to the death of cholinergic neurons observed in Alzheimer disease (2).
Gene Aliases:
NTRK1; MTC; TRK; TRK1; p140-TrkA; DKFZp781I14186
Genbank Number:
References:
1. Kaplan, D R. et al: The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science. 1991 Apr 26;252(5005):554-8.
2. Boissiere, F. et al: Neurotrophin receptors and selective loss of cholinergic neurons in Alzheimer disease. Mol Chem Neuropathol. 1996 May-Aug;28(1-3):219-23.
Specific Activity:
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
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Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~66 kDa
Krejci Pavel et al., NF449 Is a Novel Inhibitor of Fibroblast Growth Factor Receptor 3 (FGFR3) Signaling Active in Chondrocytes and Multiple Myeloma Cells Journal of Biological Chemistry July 2010 10.1074/jbc.M109.083626
Kosten Jonas et al., Efficient Modification of Alpha-Synuclein Serine 129 by Protein Kinase CK1 Requires Phosphorylation of Tyrosine 125 as a Priming Event ACS Chemical Neuroscience October 2014 10.1021/cn5002254
Krejci Pavel et al., Receptor Tyrosine Kinases Activate Canonical WNT/β-Catenin Signaling via MAP Kinase/LRP6 Pathway and Direct β-Catenin Phosphorylation PLoS One April 2012 10.1371/journal.pone.0035826
Neurobiology, Receptor Tyrosine Kinases
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