Overview:

CyclinD2 is a member of the D-type cyclins. D-type cyclins are regulators of the cell cycle and interact with several transcription factors modulating their transcriptional activations. CyclinD2 forms a complex and functions as a regulatory subunit of CDK4 or CDK6 that regulates the cell-cycle during G1/S transition. These complexes overcome the G1 growth arrest phase by phosphorylating and inactivating the retinoblastoma tumor suppressor protein (1). CyclinD2 is upregulated in the carcinogenesis of tumors, making it a possible therapeutic target for a variety of cancers, including colon cancer, stomach cancer, liver cancer, breast cancer, and lung cancer (2).

Genbank Number:

NM_001759.4

References:

1. Meyerson, M. and Harlow, E. Identification of G1 kinase activity for cdk6, a novel cyclin D partner. Mol Cell Biol. 14(3):2077-2086, 1994.
2. Chen, G. et al. miR-93-5p suppresses ovarian cancer malignancy and negatively regulate CCND2 by binding to its 3’TUR region. Discov Oncol. 13(1):15, 2022.