Enzymes, Signaling Proteins, Extracellular Ligands, Signaling Reagents, Antibodies

Catalog No.	Pack Size	Price (USD)
S52-63R-100	100 ug	$347
S52-63R-BULK	BULK	Contact Us

Catalog No.

Pack Size

Price (USD)

S52-63R-100

100 ug

$347

S52-63R-BULK

BULK

Overview:

STAT1β is a member of the signal transducers and activators of transcription (STAT) family of proteins that carry out a dual function: signal transduction and activation of transcription. STAT1β transcription factor is specific for the IFN pathway and plays a central role in mediating many, if not all, IFN-dependent biological responses (1). Presence of STAT1β leads to an efficient antiviral response when cells were infected with virus suggesting that a STAT-dependent pathway is activated following virus infection by endogenously produced IFN. Virus-induced STAT protein translocation from the cytoplasmic compartment can be detected within 3 h of infection.

References:

1. Improta, T. et al: Susceptibility to virus infection is determined by a Stat-mediated response to the autocrine effect of virus-induced type I interferon. Cytokine. 1997 Jun;9(6):383-93.

Specificity:

Recognizes the STAT1 protein

Cross Reactivity:

Western blot of human STAT1

STAT1B from other species may also be detectable.

Host:

Rabbit

Immunogen:

Synthetic peptide corresponding to amino acids 699-703 of human STAT1

Purification:

Affinity chromatography

Stability:

Store at 4°C (add 0.1% NaN₃) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Sample Data:

Representative western blot with Anti-STAT1β (1:1000) using 20 ng of GST-tagged human recombinant STAT1β, STAT2, STAT3, STAT4, STAT5, and STAT6.