FER is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. FER plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell cell interactions (1). Genetic analysis using transgenic mouse models implicate FER in the regulation of inflammation and innate immunity. Fer-deficient mice displayed enhanced recruitment of leukocytes in response to local LPS challenge. FER is required for cell-cycle progression in malignant cells. Decreasing the level of FER using RNAi impeded the proliferation of prostate and breast carcinoma cells and led to their arrest at the G0/G1 phase (2).
Fert, Fert2, AV082135, C330004K01Rik
1. Greer, P.: Closing in on the biological functions of Fps/Fes and Fer. Nat Rev Mol Cell Biol. 2002 Apr;3(4):278-89.
2. Pasder, O. et al: Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene. 2006 Jul 13;25(30):4194-206.
Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cellular Stress, Cytoplasmic Tyrosine Kinases, Invasion/Metastasis, Neurobiology