Overview:

FER is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases. FER plays a role in regulating cytoskeletal rearrangements and inside out signalling that accompany receptor ligand, cell matrix and cell cell interactions (1). Genetic analysis using transgenic mouse models implicate FER in the regulation of inflammation and innate immunity. Fer-deficient mice displayed enhanced recruitment of leukocytes in response to local LPS challenge. FER is required for cell-cycle progression in malignant cells. Decreasing the level of FER using RNAi impeded the proliferation of prostate and breast carcinoma cells and led to their arrest at the G0/G1 phase (2).

Gene Aliases:

Fert, Fert2, AV082135, C330004K01Rik

Genbank Number:

NM_001037997

References:

1. Greer, P.: Closing in on the biological functions of Fps/Fes and Fer. Nat Rev Mol Cell Biol. 2002 Apr;3(4):278-89.

2. Pasder, O. et al: Downregulation of Fer induces PP1 activation and cell-cycle arrest in malignant cells. Oncogene. 2006 Jul 13;25(30):4194-206.