Recombinant human full-length USP12 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U512-31G
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| U512-31G-05 | 5 ug | $226 | |
| U512-31G-10 | 10 ug | $325 | |
| U512-31G-BULK | BULK | Contact Us |
Overview:
Usp12 belongs to the ubiquitin-specific protease family of deubiquitinases that contains the conserved catalytic cysteine/histidine domain present in other USPs. USP12 has been identified as a deubiquitinase for histones H2A/H2B, Notch, PH domain leucine-rich repeat protein phosphatase 1, and androgen receptor (1). A complex of USP12 with WDR48 negatively regulates Akt activation, thus promoting cellular apoptosis. This complex has also been shown to suppress proliferation of tumor cell (2).
Gene Aliases:
Ubiquitin specific peptidase 12
Genbank Number:
References:
1. Joo, H. Y. et al. Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. J. Biol. Chem. 286:7190–7201, 2011.
2. Gangula, N.R. WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1). J Biol Chem. 288(48):34545-34554, 2013.
Activity:
Sample activity data. for lot-specific data, please refer to the specific datasheet.
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Purity:
Sample purity data. For lot-specific data, please refer to the specific datasheet.
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Molecular Weight:
Approx MW 68 kDa
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.
Apoptosis/Autophagy, Cancer, Cell Cycle, Cellular Stress, Inflammation, Neurobiology
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