Overview:

Ubiquitin Specific Protease 1 (USP1) is a human deubiquitinase (DUB) that contains one of the largest catalytic domains within the USP family. USP1 plays a role in regulating cellular response to DNA damage and is also involved in the control of cell differentiation (1). USP1 regulates ubiquitination of Proliferating Cell Nuclear Antigen (PCNA) in response to DNA damage preventing unscheduled recruitment of error-prone TLS DNA polymerases [2]. USP1 expression is deregulated in certain types of human cancer and is thus emerging as a novel target in cancer therapy (3).

Gene Aliases:

Ubiquitin carboxyl-terminal hydrolase 1

Genbank Number:

NM_003368

References:

1. Olazabal-Herrero, A. et al: Structure-function analysis of USP1: Insights into the role of Ser313 phosphorylation site and the effect of cancer-associated mutations on autocleavage. Mol Cancer. 14(1):33, 2015.

2. Huang, T.T. et al: Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat Cell Biol. 8:339–47, 2006.

3. García-Santisteban, I. et al: USP1 deubiquitinase: Cellular functions, regulatory mechanisms and emerging potential as target in cancer therapy. Mol Cancer 12:91, 2013.