MINDY 4 is a member of motif interacting with Ub-containing novel DUB family. It is found in all eukaryotes and selectively cleaves K48-linked polyUb, a signal that targets protein degradations (1). It has been associated with teratospermina and solid tumors including colon cancer (2,3). The expression and function of MINDY4 has yet to be characterized, however it has been shown to play a role in sustaining cell survival in vitro and regulating growth in vivo. (3)
1. Abdul Rehman SA, et al: (2016) MINDY-1 is a Member of an evolutionarily conserved and structurally distinct new family of deubiquitinating enzymes. Mol Cell. 63(1):146‐155.
2. GEO Profiles: GDS2697 record.
3. Choi ES, et al: (2018) FAM188B enhances cell survival via interaction with USP7. Cell Death Dis. 9(6):633.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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