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CYLD, Active

Recombinant human CYLD (1-956) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. C578-380G


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Catalog No. Pack Size Price (USD)
C578-380G-05 5 ug $226
C578-380G-10 10 ug $325
C578-380G-BULK BULK Contact Us  


Overview:

CYLD is a cytoplasmic deubiquitinating enzyme, which removes ubiquitin molecules from various signaling proteins, and regulates the activities of many cellular and signaling processes. It plays a role in the regulation of inflammation, immunity, cell cycle progression, spermatogenesis, osteoclastogenesis, ciliogenesis, migration and tumorigenesis. (1) Several signaling pathways, such as the Nuclear Factor-kB (NF-kB), Wnt/β-catenin and c-Jun N-terminal kinase (JNK) pathways, and potentially others have been linked with or regulated by CYLD. (2) Mutations in CYLD gene have been associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome. (3)


Gene Aliases:

EAC; MFT; SBS; TEM; BRSS; CDMT; MFT1; CYLD1; CYLDI; USPL2


Genbank Number:


References:


1. Bignell G.R. et al. Identification of the familial cylindromatosis tumour-suppressor gene. Nat Genet. 25(2):160–165, 2000.

2. Verhoeft, K.R. et al The cylindromatosis (CYLD) gene and head and neck tumorigenesis. Cancers Head Neck. 1: 10, 2016.

3. EntreZ Gene: CYLD cylindromatosis (turban tumor syndrome)


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

135 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cell Cycle, Cellular Stress, Inflammation, JNK/SAPK Pathway, WNT Signaling


RELATED PRODUCTS


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