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USP16, Active

Recombinant human USP16 (187-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. U516-381G


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Catalog No. Pack Size Price (USD)
U516-381G-05 5 ug $226
U516-381G-10 10 ug $325
U516-381G-BULK BULK Contact Us  


Overview:

USP16 (ubiquitin carboxyl-terminal hydrolase 16) is a deubiquitinating enzyme belonging to the ubiquitin-specific protease (USP) family and is involved in transcriptional regulation that controls cell differentiation, cell cycle and apoptosis through modulations with p16 Ink4a and p19 Arf. Downregulation of USP16 by truncated HBx may contribute to the growth of hepatocellular carcinoma cells (1). USP16 may also play a crucial role in provoking the self-renewal and/or senescence pathways in Down syndrome through the removal of ubiquitin from H2AK119, a critical mark for the maintenance of several somatic tissues (2).


Gene Aliases:

UBP-M


Genbank Number:


References:


1. Qian, Y. et al: USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells. Scientific Reports 6, 33039, 2016.

2. Adorno, M. et al: Usp16 contributes to somatic stem-cell defects in Down's syndrome. Nature vol. 501(7467): 380-4, 2013.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

110 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


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