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USP8, Active

Recombinant human USP8 (630-end) was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U508-381H


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Catalog No. Pack Size Price (USD)
U508-381H-05 5 ug $226
U508-381H-10 10 ug $325
U508-381H-BULK BULK Contact Us  


Overview:

USP8 (ubiquitin carboxyl-terminal hydrolase 8) is a member of the ubiquitin-specific processing protease family of proteins and is involved in the regulation of endosomal ubiquitin processes for endosome morphology, cargo sorting and membrane trafficking at the early endosome stage. USP8 deubiquitinates EPS15 and regulates EGFR degradation and MAPK signaling via removing conjugated ubiquitin from EGFR (1). USP8 also interacts with spermatid ESCRT-0 and microtubule structures in mouse species, suggesting that it may be involved in acrosome biogenesis (2).


Gene Aliases:

KIAA0055, UBPY


Genbank Number:


References:


1. Berlin, I. et al: Regulation of epidermal growth factor receptor ubiquitination and trafficking by the USP8·STAM complex. Journal of biological chemistry 285(45), 34909-21, 2010.

2. Giovanna,B. et al. USP8, a Regulator of Endosomal Sorting, Is Involved in Mouse Acrosome Biogenesis Through Interaction with the Spermatid ESCRT-0 Complex and Microtubules, Biology of Reproduction, 82(5), 930–939, 2010.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

55 kDa



Product Datasheets



Safety Datasheet



There are no related publications available for this product.


RESEARCH AREAS

Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder


RELATED PRODUCTS


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