Recombinant human USP2 (259-end), was expressed in E. coli cells using an N-terminal His tag.
Catalog No. U502-381H
Catalog No. | Pack Size | Price (USD) | |
---|---|---|---|
U502-381H-05 | 5 ug | $226 | |
U502-381H-10 | 10 ug | $325 | |
U502-381H-BULK | BULK | Contact Us |
Overview:
USP2 (Ubiquitin carboxyl-terminal hydrolase 2) is a member of the peptidase C19 superfamily and is a ubiquitin-specific protease that is essential for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. The enzyme deubiquitinates polyubiquitinated target proteins like fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. USP2 plays a role in G1/S cell-cycle progression in normal and cancer cells as it is a specific deubiquitinase for cyclin D1 (1). It is also involved in the regulation of the p53 pathway by targeting Mdm2, which is critical for maintaining genome integrity (2).
Gene Aliases:
UBP41
Genbank Number:
References:
1. Shan, J. et al: Suppression of cancer cell growth by promoting cyclin D1 degradation. Mol. Cell 36:469-476, 2009.
2. Stevenson, L. F. et al: The deubiquitinating enzyme USP2a regulates the p53 pathway by targeting Mdm2. EMBO journal 26(4): 976-986, 2007
Specific Activity:
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
40 kDa
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder
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