SENP8 (Sentrin-specific protease 8) is a cysteine protease belonging to the sentrin-specific protease family and catalyzes two crucial functions in the NEDD8 pathway. It was found that SENP8 is not a SUMO protease but functions on a small ubiquitin-related protein called NEDD8 (1). SENP8 is involved in the processing of full-length NEDD8 to its mature form and NEDD8 deconjugation from targeted proteins such as cullins or p53 (2).
DEN1, NEDP1, PRSC2
1. Mikolajczyk, J. et al: Small Ubiquitin-related Modifier (SUMO)-specific Proteases: PROFILING THE SPECIFICITIES AND ACTIVITIES OF HUMAN SENPs. The Journal of Biological Chemistry 282: 26217-26224, 2007.
2. Mendoza, H.M. et al: NEDP1, a highly conserved cysteine protease that deNEDDylates Cullins. J Biol Chem. 278(28):25637-43, 2003.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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