Sentrin-specific protease 2 (SENP2) is a protease that catalyzes the hydrolysis of an alpha-linked peptide bond of the small ubiquitin-like modifier (SUMO) propeptides leading to the mature form of the proteins and the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted protein. SENP2 plays a role in the formation of adipocytes by desumolyating and promoting CEPBP stabilization (1). SENP2 also binds to Nup153, a nucleoporin that is confined to the nucleoplasmic face of the pore and localization of SENP2 to the pore may spatially restrict the activity of this enzyme (2).
KIAA1331, SMT3IP2, AXAM2
1. Chung, S.S. et al: Control of adipogenesis by the SUMO-specific protease SENP2. Mol. Cell. Biol. 30:2135-2146, 2010.
2. Hang, J. & Dasso, M: Association of the human SUMO-1 protease SENP2 with the nuclear pore. J. Biol. Chem. 277 (22): 19961–6, 2002.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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