AMSH (STAM binding protein) is a member of the JAMM metallo-enzyme family of deubiquitinating enzymes and is a ubiquitin isopeptidase found in the endosomes. It is involved in EGFR downregulation and regulates sorting of cell-surface receptors to the lysosome. The enzyme binds to the SH3 domain of STAM, which is required for MYC and cell growth (1). It has been hypothesized that mutations in AMSH are associated with Microcephaly-capillary malformation (2).
1. McCullough, John et al: AMSH is an endosome-associated ubiquitin isopeptidase. Journal of cell biology. vol. 166,4 (2004): 487-92.
2. McDonell, Laura M et al: Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly-capillary malformation syndrome. Nature genetics 45(5): 556-62, 2013.
Sample Activity Plot. For specific information on a given lot, see related technical data sheet.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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