Neural precursor cell expressed, developmentally down-regulated 8 (NEDD8) encodes a ubiquitin-like protein (1). NEDD8 can be conjugated to proteins via the C-terminal Gly by the E2 enzyme Ubc12 and E3 ligase complex to affect various signaling molecules such as cullins, auxin, IRF3, MDM2, and p21(2). On the contrary, the NEDD8 modified substrates can be reversed by deneddylating enzymes such as CSN, NEDP1, UAP21, Ataxin3, PfUCH54, UCHL1 and UCHL3 (3). The inhibitor of NEDD8 suppressed the tumor growth in AML cells in xenograft assays (3).
1. Kamitani, T, et al. Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J. Biol. Chem. 272, 28557–28562 (1997).
2. Schmidt MHH, et al. Ubiquitin and NEDD8: brothers in arms. Sci STKE. 2006 Nov 21;2006(362).
3. Watson IR, et al. NEDD8 pathways in cancer, Sine Quibus Non. Cancer Cell. 2011 Feb 15;19(2):168-76.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Neurobiology