Ubiquitin carboxyl-terminal hydrolase 51 (USP51) contains the Zn-finger ZnF-UBP domain and belongs to a subfamily of deubiquitinating enzymes (DUBs) (1). USP51 regulates DNA damage response through deubiquitylating histone H2A Lys 13,15ub at the DNA double-strand breaks (2). USP51 deubiquitinates and stabilizes ZEB1 to regulate cell invasion and epithelial-mesenchymal transition in the breast cancer cells and is overexpressed in breast cancer patients and associated to poor survival (3).
Ubiquitin carboxyl-terminal hydrolase 51
1. Quesada V, et al. Cloning and enzymatic analysis of 22 novel human ubiquitin-specific proteases. Biochem Biophys Res Commun. 2004 Jan 30; 314(1):54-62.
2. Wang Z, et al. USP51 deubiquitylates H2AK13,15ub and regulates DNA damage response. Genes Dev. 2016 Apr 15; 30(8):946-59.
3. Zhou Z, et al. USP51 promotes deubiquitination and stabilization of ZEB1. Am J Cancer Res. 2017 Oct 1; 7(10):2020-2031.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
There are no related publications available for this product.
Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder