Overview:

Ubiquitin carboxyl-terminal hydrolase 25 (USP25) belongs to the ubiquitin-specific proteases (USPs) family, and removes conjugated ubiquitin from substrates (1). USP25 processes, recycles ubiquitin to prevent the proteasomal degradation of proteins (1). It modifies tetraubiquitin chains via hydrolysing ‘Lys-63’ linked polyubiquitins to negatively regulate the inflammation mediated by IL-17 (2). A genome-wide association study of inflammatory bowel disease (IBD) identified the SNPs at USP25 sites (3).

Gene Aliases:

USP21

Genbank Number:

NM_013396

References:

1. Valero R, et al. USP25, a novel gene encoding a deubiquitinating enzyme, is located in the gene-poor region 21q11.2. Genomics. 1999 Dec 15;62(3):395-405.

2. Zhong B, et al. Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25. Nat Immunol. 2012 Nov; 13(11):1110-7.

3. Brant SR, et al. Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2017 Jan; 152 (1):206-217.