Overview:

OTUB1 (OTU domain-containing ubiquitin aldehyde-binding protein 1), as a member of the ovarian tumor (OUT) superfamily of predicted cysteine proteases (1). It specifically cleaves ubiquitin from branched lysine48-linked poly-ubiquitin chains (1). OTUB1 inhibits the synthesis of the K63-linked polyubiquitin chains through binding to the UBC13 (2). Overexpression of OTUB1 is associated to poor outcome in some breast cancer patients with chemotherapy (3).

Gene Aliases:

OTB1; OTU1; HSPC263; OTU deubiquitinase, ubiquitin aldehyde binding 1

Genbank Number:

NM_017670

References:

1. Edelmann MJ, et al. Structural basis and specificity of human otubain 1-mediated deubiquitination. Biochem J. 2009 Mar 1;418(2):379-90.

2. Wiener R, et al. The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature. 2012 Feb 22;483(7391):618-22.

3. Karunarathna U, et al. OTUB1 inhibits the ubiquitination and degradation of FOXM1 in breast cancer and epirubicin resistance. Oncogene. 2016 Mar 17;35(11):1433-44.