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OTULIN, Protein

Recombinant full-length human OTULIN was expressed in E. coli cells using an N-terminal His tag.
Catalog No. O585-30H

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Catalog No. Pack Size Price (USD)
O585-30H-20 20 ug $215
O585-30H-50 50 ug $435
O585-30H-BULK BULK Contact Us  


OTULIN (OTU deubiquitinase with linear linkage specificity) belongs to the family of peptidase C65 family of ubiquitin isopeptidases via removing ubiquitin from proteins (1). OTULIN specifically targets on Met1-linked polyubiquitin chains to repress the linear ubiquitin chain assembly complex (LUBAC) mediated ubiqitination (2). OTULIN deficiency leads to a TNF-related systemic inflammation and aotuimmunity in humans and mice model, and the neutralizing antibody can rescue the phenotypes (3).

Gene Aliases:


Genbank Number:


1. Mevissen TE, et al. OTU deubiquitinases reveal mechanisms of linkage specificity and enable ubiquitin chain restriction analysis. Cell. 2013 Jul 3;154(1):169-84.

2. Keusekotten K, et al. OTULIN antagonizes LUBAC signaling by specifically hydrolyzing Met1-linked polyubiquitin. Cell. 2013 Jun 6;153(6):1312-26.

3. Damgaard RB, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016 Aug 25;166(5):1215-1230.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

49 kDa

Product Datasheets

Safety Datasheet

There are no related publications available for this product.


Cancer, Cardiovascular Disease, Cell Cycle, Cellular Stress, Invasion/Metastasis, Metabolic Disorder



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