WDR5 Protein
Full-length recombinant human WDR5 was expressed in E. coli cells using an N-terminal His tag.
Catalog No. W325-30H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| W325-30H-20 | 20 ug | $215 | |
| W325-30H-50 | 50 ug | $435 | |
| W325-30H-BULK | BULK | Contact Us |
Full-length recombinant human WDR5 was expressed in E. coli cells using an N-terminal His tag.
Catalog No. W325-30H
| Catalog No. | Pack Size | Price (USD) | |
|---|---|---|---|
| W325-30H-20 | 20 ug | $215 | |
| W325-30H-50 | 50 ug | $435 | |
| W325-30H-BULK | BULK | Contact Us |
Overview:
WD repeat-containing protein 5 (WDR5) is a conserved subunit of Trithorax (TRX) histone methyltransferase complexes. Selectively binds dimethylated Lys4 (K4me2) in histone H3 to promote K4 trimethylation by TRX.
Gene Aliases:
BIG3; BIG-3
Genbank Number:
References:
1. Couture JF, et al: Molecular recognition of histone H3 by the WD40 protein WDR5. Nat Struct Mol Biol. 2006 13(8):698-703.
2. Han Z, et al: Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5. Mol Cell. 2006 22(1):137-44.
Purity:
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight:
~40 kDa
Cancer, Inflammation, Metabolic Disorder
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Karakkat JV et al., The metabolic sensor PASK is a histone 3 kinase that also regulates H3K4 methylation by associating with H3K4 MLL2 methyltransferase complex. Nucleic Acids Research September 2019 10.1093/nar/gkz786
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