1-phosphatidylinositol 4, 5-bisphosphate phosphodi-esterase delta-4 (PLCD4) is one of the subtypes of phosphoinositide-specific phospholipase C (PI-PLC. Hydrolyzes the phosphatidylinositol 4, 5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3). PLCD4 has been implicated to have a key role in cell proliferation. It was found that aberrant expression of PLCD4 may cause oncogenesis in certain tissues through upregulation of ErbB and activation of ERK pathway.
EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCD4A; PLCD4B
1. Leung DW, et al: Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. Mol Cancer. 3:15, 2004.
2. Liu N, et al: A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. J Biol Chem. 271(1): 355-60, 1996.
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Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder