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PLCD4 Protein

Recombinant full-length human PLCD4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P442-30DG


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Catalog No. Pack Size Price (USD)
P442-30DG-20 20 ug $314
P442-30DG-50 50 ug $545
P442-30DG-BULK BULK Contact Us  


Overview:

1-phosphatidylinositol 4, 5-bisphosphate phosphodi-esterase delta-4 (PLCD4) is one of the subtypes of phosphoinositide-specific phospholipase C (PI-PLC. Hydrolyzes the phosphatidylinositol 4, 5-bisphosphate (PIP2) to generate 2 second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3). PLCD4 has been implicated to have a key role in cell proliferation. It was found that aberrant expression of PLCD4 may cause oncogenesis in certain tissues through upregulation of ErbB and activation of ERK pathway.


Gene Aliases:

EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCD4A; PLCD4B


Genbank Number:


References:


1. Leung DW, et al: Phospholipase C delta-4 overexpression upregulates ErbB1/2 expression, Erk signaling pathway, and proliferation in MCF-7 cells. Mol Cancer. 3:15, 2004.

2. Liu N, et al: A new phospholipase C delta 4 is induced at S-phase of the cell cycle and appears in the nucleus. J Biol Chem. 271(1): 355-60, 1996.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

110 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Cell Cycle, ERK/MAPK Pathway, Metabolic Disorder


RELATED PRODUCTS


  PLCB1 Protein, P441-30G


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