1-phosphatidylinositol 4, 5-bisphosphate phosphodiester-ase beta-1 (PLCB1) is one of the best characterized isoenzymes in the inositide specific phospholipase C (PI-PLC) family. Responsible for the hydrolysis of the phosphatidilinool-4, 5-bisphophate (PIP2), generating the second messengers inositol-1, 4, 5-triphosphate and di-acylglycerol. It is a key molecule for nuclear inositide signaling, where it plays a role in cell cycle progression, proliferation and differentiation.
EIEE12; PI-PLC; PLC-154; PLC-I; PLC154; PLCB1A; PLCB1B
1. Faenza I, et al: A role for PLCbeta1 in myotonic dystrophies type 1 and 2. Faseb J. 26:3042–3048, 2012.
2. Faenza I, et al: Nuclear inositide specific phospholipase C signalling - interactions and activity. FEBS J. 280(24):6311-21, 2013.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability, and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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