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PAD4, Active

Recombinant full-length human PAD4 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. P312-310DG


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Catalog No. Pack Size Price (USD)
P312-310DG-05 5 ug $226
P312-310DG-10 10 ug $325
P312-310DG-BULK BULK Contact Us  


Overview:

PAD4 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions (1). PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps (NETs) (2). PAD4 play a role in granulocyte and macrophage development leading to inflammation and immune response. PAD4 also mediates the gene expression by regulating arginine methylation and citrullination in histones (3).


Gene Aliases:

PADI4; PAD; PDI4; PDI5


Genbank Number:


References:


1. Nakashima, K. et.al: Molecular characterization of peptidylarginine deiminase in HL-60 cells induced by retinoic acid and 1-alpha,25-dihydroxyvitamin D(3). J. Biol. Chem. 274: 27786-27792, 1999.

2. Li, P.et.al: PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J. Exp. Med. 207: 1853-1862, 2010.

3. Wang, Y. et.al: Human PAD4 regulates histone arginine methylation levels via demethylimination. Science 306: 279-283, 2004.


Specific Activity:

Sample Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

96 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Inflammation


RELATED PRODUCTS


  PAD3, Active, P312-310CG

  PAD Detection Kit, P312-863

  PAD2 (human) Inhibitor Screening Kit, P318BG-863

  PAD4 Inhibitor Screening Kit, P310DG-863


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