Overview:

SETD7 or SET domain containing lysine methyltransferase 7 is a lysine methyltransferase which can methylates lysine-4 (K4) in histone H3 in vitro and in vivo. Methylation of K4 in histone H3 by SETD7 and methylation of K9 in histone H3 by SUV39H1 were found to have differential effects on subsequent histone acetylation by p300 (1). SETD7 can also methylate p53 at lys372 within the C-terminal regulatory region (2). Methylated p53 is restricted to the nucleus and the modification positively affects its stability. SETD7 regulates the expression of p53 target genes in a manner dependent on the p53 methylation site.

Gene Aliases:

FLJ21193; KIAA1717; KMT7; SET7; SET7/9; SET9

Genbank Number:

NM_030648

References:

1. Wang, H. et al: Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase. Molec. Cell 8: 1207-1217, 2001.

2. Chuikov, S. et al: Regulation of p53 activity through lysine methylation. Nature 432: 353-360, 2004.