Mitogen-acitvated protein kinase kinase 3 (MEK3) is a serine/threonine kinase that is involved in the activation of MAP kinases. MEK3 is a dual-specificity protein kinase that phosphorylates p38 MAP kinase at its activation site Thr-Gly-Tyr and this stimulates the ability of p38 MAPK to phosphorylate protein substrates such as ATF-2 and Elk-1. MEK3 is activated by different forms of cellular stress and inflammatory cytokines. MEK3-null mice are viable and fertile, but their macrophages and dendritic cells are defective in IL-12 production (1). A virulence factor from Yersinia pseudotuberculosis, YopJ, was found to bind directly to MEK3 in vitro and this leads to blockage of its phosphorylation and activation (2).
MAP2K3, MEK3, MAPKK3, PRKMK3, SKK2
1. Lu, H.-T. et al: Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (MEK3)-deficient mice. EMBO J. 18: 1845-1857, 1999.
2. Orth, K. et al: Inhibition of the mitogen-activated protein kinase kinase superfamily by a Yersinia effector. Science 285: 1920-1923, 1999.
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Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Angiogenesis, Apoptosis/Autophagy, Cancer, Cardiovascular Disease, ERK/MAPK Pathway, Invasion/Metastasis, Neurobiology, Ser/Thr Kinases