Home   >    Enzymes   >   Protein Kinases

JNK2, Unactive

Recombinant full-length rat JNK2 was expressed in E. coli cells using an N-terminal GST tag.
Catalog No. M34-14G


Shop Online



Catalog No. Pack Size Price (USD)
M34-14G-20 20 ug $215
M34-14G-50 50 ug $435
M34-14G-BULK BULK Contact Us  


Overview:

JNK2 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation and treatment of cells with TNFα. JNK2 binds to the c-Jun transactivation domain and phosphorylates it on Ser-63 and Ser-73 (1). JNK2 has been shown to play an important role in disease processes. JNK2 plays a role in ventricular hypertrophy and is thought to be involved in hypertensive cardiac disease (2).


Gene Aliases:

SAPK; MAPK9


Genbank Number:


References:


1. Sluss, H K. et al: Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol Cell Biol. 1994 Dec;14(12):8376-84.

2. Vogel, V. et al: Cardiac hypertrophy in the Prague-hypertensive rat is associated with enhanced JNK2 but not ERK tissue activity. Kidney Blood Press Res. 2001;24(1):52-6.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~74 kDa



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, JNK/SAPK Pathway, Neurobiology, NfkB Pathway, Ser/Thr Kinases


RELATED PRODUCTS


  IRAK4, Active, I12-10G

  SMAD3 Protein, S12-30G

  MEKK3, Active, M11-10G

  MEK7, Active, M08-10G


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox