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Anti-PKC mu

Rabbit Polyclonal Antibody
Catalog No. P72-63R


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Catalog No. Pack Size Price (USD)
P72-63R-100 100 ug $347
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Overview:

Protein kinase C mu (PKCμ) is a member of the protein kinase C (PKC) family that differs from the other PKC isoenzymes in structural and enzymatic properties. PKCμ is a ubiquitous in nature with the highest expression in the thymus, lung and peripheral blood mononuclear cells (1). PKCμ forms a complex in vivo with a phosphatidylinositol 4-kinase and a phosphatidylinositol-4-phosphate 5-kinase. A region of PKCμ between the amino-terminal transmembrane domain and the pleckstrin homology domain is shown to be involved in the association with the lipid kinases (2).

References:


1. Rennecke, J. et al: Immunological demonstration of protein kinase C mu in murine tissues and various cell lines. Eur J Biochem. 1996 Dec 1;242(2):428-32.

2. Nishikawa, K. et al: Association of protein kinase Cmu with type II phosphatidylinositol 4-kinase and type phosphatidylinositol-4-phosphate 5-kinase. J Biol Chem. 1998 Sep 4;273(36):23126-33.


Specificity:

Recognizes the PKCμ protein


Cross Reactivity:

Western blot human PKCu

PKCu from other species may also be detectable.


Host:

Rabbit


Immunogen:

Synthetic peptide corresponding to amino acids 736-740 of human PKCμ


Purification:

Affinity chromatography


Stability:

Store at 4oC (add 0.1% NaN3) for several months, and at -20oC for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Sample Data:

Representative immunoprecipitation (left image) with 2 μg of Anti- PKCμ using 500 μg of HEK-293T cell lysate. Representative western blot (right image) with Anti- PKCμ (1:1000) using 3 μg, 10 μg, and 30 μg of HEK-293T cell lysate.


Sample Data:

Representative western blot with Anti- PKCμ (1:1000) using 20ng of GST-tagged human recombinant PKCα, PKCβI, PKCβII, PKCγ, PKCδ, PKCε, PKCη, PKCθ, PKCμ, PKCν, PKCζ, and PKCι.



Product Datasheets



RESEARCH AREAS

Apoptosis/Autophagy, Cardiovascular Disease, ERK/MAPK Pathway, Inflammation, Invasion/Metastasis, Metabolic Disorder, Neurobiology, NfkB Pathway, PKA/PKC Pathway


RELATED PRODUCTS


  PKC gamma, Active, P66-10G

  PKC beta I, Active, P62-10G

  PKCtide, P15-58

  Anti-PKC zeta, P75-63R


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