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Anti-p38 alpha

Rabbit Polyclonal Antibody
Catalog No. M39-63R


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Catalog No. Pack Size Price (USD)
M39-63R-25 25 ug $127
M39-63R-100 100 ug $347
M39-63R-BULK BULK Contact Us  


Overview:

p38α (SAPK2A) is a member of the p38 MAPK family which are activated by various environmental stresses and proinflammatory cytokines (1). The activation of p38 requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase (2). The substrates of p38 include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response (5).

References:

1. Han, J. et al: A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.

2. Ge, B. et al: MAPKK-independent activation of p38-alpha mediated by TAB1-dependent autophosphorylation of p38-alpha. Science 295: 1291-1294, 2002.


Specificity:

Recognizes the p38α protein


Cross Reactivity:

Western blot human p38a

p38a from other species may also be detectable.


Host:

Rabbit


Immunogen:

C-terminal peptide of p38α conjugated to ovalbumin


Purification:

Affinity chromatography


Stability:

Store at 4°C (add 0.1% NaN3) for several months, and at -20°C for longer periods. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Sample Western Blot:


Representative western blot (1:1000) using 20ng of p38α, p38β, p38γ, and p38δ recombinant protein.



Product Datasheets



RESEARCH AREAS

Angiogenesis, Apoptosis/Autophagy, Cardiovascular Disease, Cellular Stress, Inflammation, Metabolic Disorder, Neurobiology, NfkB Pathway, p38 Pathway


RELATED PRODUCTS


  p38 alpha (K53A), Unactive, M39-16H

  p38 alpha, Active, M39-10BG

  p38 beta, Active, M36-10BG

  p38 delta, Active, M38-10BG


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