Home   >    Proteins   >   Mutant Kinases

ALK2 (R206H), Active

Recombinant human ALK2 (R206H) (147-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. A06-12BG


Shop Online



Catalog No. Pack Size Price (USD)
A06-12BG-05 5 ug $226
A06-12BG-10 10 ug $325
A06-12BG-BULK BULK Contact Us  


Overview:

ALK2 belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins which encodes activin A type I receptor. ALK2 signals a particular transcriptional response in concert with activin type II receptors. Mutations in ALK2 are associated with fibrodysplasia ossificans progressiva (FOP) and the mutations are located in or adjacent to the GS regulatory region or active site of the kinase. The mutations in ALK2 were predicted by protein structure homology modeling to activate the ALK2 protein and enhance receptor signaling (1). Dysregulated ALK2 kinase activity plays a role in the pathogenesis of FOP (2).


Gene Aliases:

ACVR1, FOP, SKR1, TSRI, ACTRI, ACVR1A, ACVRLK2


Genbank Number:


References:


1. Kaplan, F. S.et.al:Classic and atypical fibrodysplasia ossificans progressiva (FOP) phenotypes are caused by mutations in the bone morphogenetic protein (BMP) type I receptor ACVR1. Hum. Mutat. 30: 379-390, 2009.

2. Yu, P. B.et.al: BMP type I receptor inhibition reduces heterotropic ossification. Nature Med. 14: 1363-1369, 2008.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~67 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

AKT/PKB Pathway, Angiogenesis, Cancer, Cardiovascular Disease, JAK/STAT Pathway, Neurobiology, Ser/Thr Kinases


RELATED PRODUCTS


  Kinase Dilution Buffer III, K23-09

  Kinase Assay Buffer I, K01-09

  ATP Stock Solution, A50-09

  Casein Protein, C03-54N


SIGNALCHEM BIOTECH INC.


About

Terms of Service

Privacy Policy

Get the latest resources, updates and offers in your inbox