Overview:

HDAC8 or Histone deacetylase 8 belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. The protein encoded by this gene belongs to class I of the histone deacetylase family that catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors (1). There are 2 adjacent histidine residues in the predicted active site (His142 and His143) that are required for HDAC activity on H4 peptide substrates and core histones (2). The knockdown of HDAC8 by RNA interference inhibited the growth of human lung, colon, and cervical cancer cell lines.

Gene Aliases:

HDACL1; RPD3

Genbank Number:

BC050433

References:

1. Buggy, J. J. et.al: Cloning and characterization of a novel human histone deacetylase, HDAC8. Biochem. J. 350: 199-205, 2000.

2. Vannini, A. et.al: Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor. Proc. Nat. Acad. Sci. 101: 15064-15069, 2004.