Overview:

High temperature requirement protein A2 (HTRA2) is a serine protease that normally resides in mitochondrial membranes and plays a key role in the apoptosis pathways in different pathological conditions including myocardial ischemia/reperfusion injury. Heart ischemia /reperfusion induced HTRA2 translocation from the mitochondria to the cytosol promotes cardiomyocyte apoptosis via a protease activity-dependent and caspase-mediated pathway.

Gene Aliases:

OMI; PARK13; PRSS25

Genbank Number:

NM_013247

References:

1. Suzuki Y, et al: Mitochondrial protease Omi/HtrA2 enhances caspase activation through multiple pathways. Cell Death Differ 11:208–216. 2004

2. Bhuiyan MS, et al: Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia/reperfusion injury. Cardio-vasc Ther. 26(3):224-32. 2008