Overview:

NPR2 encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides which produce cytoplasmic cyclic GMP from GTP on binding its extracellular ligand, C-type natriuretic peptide (1).The granulosa cell ligand NPPC and its receptor NPR2 in cumulus cells prevent precocious meiotic maturation which is critical for maturation and ovulation synchrony and for normal female fertility. NPR2 is critical for the development of both bone and female reproductive organs (2).

Gene Aliases:

AMDM; ANPB; ANPRB; GUC2B; GUCY2B; NPRB; NPRBi

Genbank Number:

NM_003995

References:

1. Lincoln, T. M.et.al: Intracellular cyclic GMP receptor proteins. FASEB J. 7: 328-338, 1993.

2. Tamura, N.et.al: Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc. Nat. Acad. Sci. 101: 17300-17305, 2004.