Overview:

MEF2A (Myocyte Enhancer Factor 2A) is a transcription factor that belongs to the Myocyte Enhancer Factor 2 (MEF2) family of proteins. MEF2A plays a crucial role in the regulation of gene expression during cell growth and differentiation, particularly in muscle cells. It is activated by various signaling pathways, including the calcineurin/NFAT pathway, and binds to the MEF2-binding element (MBE) in the promoter region of target genes to promote their transcription. MEF2A has been implicated in a variety of physiological processes, including muscle development and function, cardiovascular development, and neural development. Dysregulation of MEF2A has been observed in various types of cancer, including breast cancer, and it has been proposed as a potential therapeutic target.

Genbank Number:

Q02078

References:

1. Olson, T.M. & Arnett, J.L.: MEF2 transcription factors: regulators of diverse developmental processes. Dev. Biol. 2009, 328(2): 153-162.