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Tau-441, BRSK2-phosphorylated

Recombinant human tag-free Tau-441 was co-expressed with BRSK2 in E. coli cells. The Tau-441 was phosphorylated by BRSK2 in vivo and in vitro prior to the final chromatography purification.
Catalog No. T08-50BN


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Catalog No. Pack Size Price (USD)
T08-50BN-20 20 ug $215
T08-50BN-50 50 ug $435
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Overview:

Tau-441 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, beta-amyloid precursor protein (betaAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).


Gene Aliases:

Tau-F, (N2R4), Tau-4, MAPT, MSTD, PPND, DDPAC, MAPTL, MTBT1, MTBT2, FTDP-17, FLJ31424, MGC138549


Genbank Number:


References:


1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.

2. Rial, A. et al: Calcium Dyshomeostasis in beta-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532


Purity:

SDS-PAGE image of purified Tau Proteins. Lane 1, Tau-441, BRSK2-phosphorylated. Lane 2, Tau-441 Protein, Cat. # T08-54N.


Tau Proteins:

Representation of seven Tau proteins, from top to bottom: Tau-441, Tau-410, Tau-412, Tau-381, Tau-383, Tau-352 and Tau-316 (Tau Protein Marker; Cat # T08-07N).


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~64 kDa



Product Datasheets



RESEARCH AREAS

Invasion/Metastasis, Neurobiology, p38 Pathway


RELATED PRODUCTS


  Tau-352 Protein, T03-54N

  Tau-441, CAMK2-phosphorylated, T08-50CN

  Tau-441, PHKG2-phosphorylated, T08-50KN

  Tau-441, PKA-phosphorylated, T08-50LN


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