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Tau-412, GSK3beta-phosphorylated

Recombinant human tag-free Tau-412 was co-expressed with GSK3beta in E. coli cells. The Tau-412 protein was phosphorylated by GSK3beta in vivo and in vitro prior to the final chromatography purification
Catalog No. T07-50CN


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Catalog No. Pack Size Price (USD)
T07-50CN-20 20 ug $215
T07-50CN-50 50 ug $435
T07-50CN-BULK BULK Contact Us  


Overview:

Tau-412 or Tau-F is a member of the Tau family of proteins which function to stabilize the microtubules by binding to them. Tau proteins are subject to phosphorylation and this phenomenon regulates the association of the Tau protein with the microtubules (1). Deposits of Alzheimer's disease AD-associated proteins, such as hyperphosphorylated Tau, as well as other shared misfolded proteins, such as, β-amyloid precursor protein (βAPP), ubiquitin, and various chaperones and protein kinases are thought to play a pathologic role in the cognitive decline and muscular failure. Malfunctioning of Tau proteins is associated with microtubules disintegration and collapsing of the neuronal transport system (2).


Gene Aliases:

Tau-F, (N2R4), Tau-4, MAPT, MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; FLJ31424; MGC138549


Genbank Number:


References:


1. Zilka, N., et al. Truncated tau from sporadic Alzheimer's disease suffices to drive neurofibrillary degeneration in vivo. FEBS Lett. 2006; 508: 3582-3588.

2. Rial, A. et al: Calcium Dyshomeostasis in beta-Amyloid and Tau-bearing Skeletal Myotubes. J. Biol. Chem., 2004; 279: 3524-53532.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Tau Proteins:

Representation of seven Tau proteins, from top to bottom: Tau-441, Tau-410, Tau-412, Tau-381, Tau-383, Tau-352 and Tau-316


Storage, Stability, and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

58 kDa



Product Datasheets



There are no related publications available for this product.


RESEARCH AREAS

Invasion/Metastasis, Neurobiology, p38 Pathway


RELATED PRODUCTS


  Tau Protein Marker, T08-07N

  Tau-412 Protein, T07-54N

  Tau-441, GSK3beta-phosphorylated, T08-50FN

  Tau-441 Protein, T08-54N


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