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Anti-2019-nCoV Spike Protein Neutralizing Nanobody (NBX20014)

Recombinant Llama VHH antibody for studying neutralization of SARS-CoV-2 and detection of 2019 -nCoV Spike Protein.
Catalog No. C19S1-654L

Catalog No. Pack Size Price (USD)
C19S1-654L-20 20 ug $165
C19S1-654L-100 100 ug $325
C19S1-654L-BULK BULK Contact Us  


The severe acute respiratory syndrome related novel coronavirus SARS-CoV-2 has caused the pandemic of the respiratory diseases (COVID-19) around the world in 2020 (1). The spike glycoprotein (S) of coronavirus belongs to the type I transmembrane protein containing two subunits, S1 and S2 (2), which is also known to be the key component to bind with host cells through the interaction with angiotensin-converting enzyme 2 (ACE2). A receptor binding domain (RBD) of S1 can recognize the cell surface receptor and the mutation of RBD could cause higher motility rate (3).


1. Zhou P, et al: A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, 579:270-89.

2. Xiao X, et al: The SARS-CoV S glycoprotein. Cell Mol Life Sci. 2004, 61 (19-20): 2428-30.

3. Lan J, et al: Crystal structure of the 2019-nCov spike receptor-binding domain bound with the ACE2 receptor. bioRxiv. doi: https://doi.org/10.1101/2020.02.19.956235.


Recognizes the 2019-nCoV Spike protein. Neutralizing activity validated for wild type Spike protein RBD , Spike protein RBD (N501Y) variant, and triple mutant (K417N, E484K, N501Y) RBD.

Assay Data :

Sample assay data. For lot-specific data please refer to lot-specific datasheet.

Assay Data :

Sample assay data. For lot-specific data please refer to lot-specific datasheet.


Llama VHH

Product Datasheets

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Acute Respiratory Distress Syndrome , Cell Cycle, Cellular Stress, COVID19, Gastrointestinal Diseases , Infectious Diseases , Inflammation, Lung Diseases , Neurobiology, severe acute respiratory syndrome coronavirus 2 , Virology



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