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c-MER (A708S), Active

Recombinant human c-MER (A708S) (578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M51-12BG


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Catalog No. Pack Size Price (USD)
M51-12BG-05 5 ug $226
M51-12BG-10 10 ug $325
M51-12BG-BULK BULK Contact Us  


Overview:

c-MER is a member of the TYRO3/AXL/MER (TAM) receptor kinase family which encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses (1). c-MER is essential regulators of mammalian spermatogenesis (2). Mutations in c-MER gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).


Gene Aliases:

MERTK


Genbank Number:


References:


1. Rothlin, C. V.et.al: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136, 2007.

2. Lu, Q.et.al: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728, 1999.


Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Purity:

Sample Purity Data. For specific information on a given lot, see related technical data sheet.


Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.


Molecular Weight:

~58 kDa



Product Datasheets



RESEARCH AREAS

Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, Neurobiology


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