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c-MER (A708S), Active

Recombinant human c-MER (A708S) (578-872) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
Catalog No. M51-12BG

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Catalog No. Pack Size Price (USD)
M51-12BG-05 5 ug $226
M51-12BG-10 10 ug $325
M51-12BG-BULK BULK Contact Us  


c-MER is a member of the TYRO3/AXL/MER (TAM) receptor kinase family which encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Cytokine-dependent activation of TAM signaling diverts a proinflammatory pathway to provide an intrinsic feedback inhibitor of both TLR- and cytokine-driven immune responses (1). c-MER is essential regulators of mammalian spermatogenesis (2). Mutations in c-MER gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).

Gene Aliases:


Genbank Number:


1. Rothlin, C. V.et.al: TAM receptors are pleiotropic inhibitors of the innate immune response. Cell 131: 1124-1136, 2007.

2. Lu, Q.et.al: Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature 398: 723-728, 1999.

Specific Activity:

Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.


Sample Purity Data. For specific information on a given lot, see related technical data sheet.

Storage, Stability and Shipping:

Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

Molecular Weight:

~58 kDa

Product Datasheets


Cancer, Cytoplasmic Tyrosine Kinases, Inflammation, Neurobiology


  Kinase Dilution Buffer IV, K24-09

  Kinase Assay Buffer II, K02-09

  ATP Stock Solution, A50-09

  Poly (4:1 Glu, Tyr) Peptide, P61-58



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