Recombinant human SUMO1 (UBL1) (2-97) was expressed in E. coli cells using an N-terminal His tag.
Catalog No. S293-31H
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SUMO1 (also known as UBL1) is a member of the SUMO (small ubiquitin-like modifier) protein family which functions in a manner similar to ubiquitin. SUMO1 is bound to target proteins as part of a post-translational modification system and it is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (1). SUMO1 may be involved in the repair of TOP1-mediated DNA damage (2). The sumoylation pathway plays a significant role in mammalian DNA damage response.
UBL1; DAP1; GMP1; SMT3; OFC10; SENP2; SMT3C; SMT3H3; PIC1
1. Su, H.-L. et.al: Molecular features of human ubiquitin-like SUMO genes and their encoded proteins. Gene 296: 65-73, 2002.
2. Mao, Y. et.al: SUMO-1 conjugation to topoisomerase I: a possible repair response to topoisomerase-mediated DNA damage. Proc. Nat. Acad. Sci. 97: 4046-4051, 2000.
Sample Purity Data. For specific information on a given lot, see related technical data sheet.
Storage, Stability and Shipping:
Store product at –70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
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Apoptosis/Autophagy, Cell Cycle, NfkB Pathway